Journal of Visualized Experiment (JoVE)

JoVE creates the ultimate solutions for advancing research and science education by making and publishing videos of scientific experiments from the top laboratories around the globe.

Deep Brain Stimulation

Human:

Joy Tan, et al. An Instrumented Pull Test to Characterize Postural Responses. 2019

Sebastian Moeller, et al. Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression. 2018

Andrew P. Janson, et al. Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy UsingInteractive, Patient-Specific Models. 2018       

Ying Meng, et al. MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor. 2017

Kyle M. Koss, et al. Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation. 2017

Martin Jakobs, et al. Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain. 2017

Carlos Trenado, et al. Combined Invasive Subcortical and Non-invasive Surface NeurophysiologicalRecordings for the Assessment of Cognitive and Emotional Functions inHumans. 2016

Ancor Sanz-García, et al. Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistantTemporal Lobe Epilepsy Patients. 2016

Simon Little, et al. Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation. 2014

Animal:

Andrea Slezia, Christopher M. Proctor, et al. Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. 2019.

Gabriella Panuccio, et al. Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays. 2018

Zhe Zhao, et al. An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation. 2018

Jens K. Haumesser, et al. Acute InVivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats. 2017

Liana Melo-Thomas, et al. a Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats. 2017

Carsten R. Bjarkam, et al. Exposure of the Pig CNS for Histological Analysis: A Manual for Decapitation, Skull Opening, and Brain Removal. 2017

Vinita Batra, et al. A General Method for Evaluating Deep Brain Stimulation Effects onIntravenous Methamphetamine Self-Administration. 2016

Francisco J. Urbano, et al. Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons. 2016

Marta Rattka, et al. A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test. 2015

Felix Fluri, et al. Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation. 2015

Max F.K. Happel, et al. Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning. 2015

Robert D. Kirch, et al. The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents. 2015

Tharakeswari Selvakumar, et al. Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus. 2015

Pei-Lu Yi, Shuo-Bin Jou, et al. Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture. 2016

Koral Goltseker, Roni Yankelevitch-Yahav, Noa S. Albelda, Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder, 2015

Transcranial direct current stimulation(tDCS

Human:

Charalambos C. Charalambous, et al. Bilateral Assessment of the Corticospinal Pathways of the Ankle Muscles Using Navigated Transcranial Magnetic Stimulation. 2019

Adrianna Giuffre, et al. Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain. 2019

Faddi G. Saleh Velez, et al. Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain. 2019

Sebastian Moeller, et al. Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression. 2018.

Fabiana Carvalho, et al. Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients. 2018

Pantelis Lioumis, et al. Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex. 2018

Andrew P. Janson, et al. Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy UsingInteractive, Patient-Specific Models, 2018       

Marcus Yu Bin Pai, et al. The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb. 2018      

Michael T. Shaw, et al. Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability. 2017

Marco Curado, et al. Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function. 2016

Margaret Kasschau, et al. A Protocol for the Use of Remotely-Supervised Transcranial Direct CurrentStimulation (tDCS) in Multiple Sclerosis (MS). 2015

Paul A. Pope. Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum. 2015

Katharine Dunlop, et al. MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder. 2015

Sara Tremblay, et al. The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism. 2014

Animal:

Andrea Slezia, Christopher M. Proctor, et al. Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. 2019.

Gábor Kozák, et al. Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats. 2018

Eduardo de Souza Nicolau, et al. Transcranial Direct Current Stimulation (tDCS) in Mice. 2018

Brita Fritsch, et al. Transcranial Electrical Brain Stimulation in Alert Rodents. 2017

Hsiang-Chin Lu, et al. Direct-current Stimulation and Multi-electrode Array Recording of Seizure-likeActivity in Mice Brain Slice Preparation. 2016

Mauricio F. Villamar et al. Technique and Considerations in the Use of 4×1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS). 2013

Transcranial alternating current stimulation(tACS)

Human:

Kathleen A. Williams, et al. Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging. 2017

Anna Shpektor, et al. Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation. 2017

Kristoffer D. Fehér, et al. Concurrent Electroencephalography Recording During Transcranial Alternating Current Stimulation (tACS). 2016

Marco Curado, et al. Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function. 2016

Sara Tremblay, et al. The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism. 2014

Animal:

Brita Fritsch, et al. Transcranial Electrical Brain Stimulation in Alert Rodents. 2017

Transcranial magnetic stimulation (TMS

Human:

Adrianna Giuffre, et al. Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain. 2019

Sebastian Moeller, et al. Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression. 2018.

Colin Holbrook, et al. Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses. 2018

Pantelis Lioumis, et al. Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex. 2018

Fabiana Carvalho, et al. Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients. 2018

Michael D. Guthrie, et al. Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition. 2018

Yves-Alain Kuhn, et al. Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention. 2017

Martin Jakobs, et al. Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain. 2017

Anna Shpektor, et al. Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation. 2017

Aron Tendler, et al. How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression. 2017

Mouhsin M. Shafi, et al. A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy. 2016

Michael J. Asmussen, et al. Combining Multiple Data Acquisition Systems to Study Corticospinal Outputand Multi-segment Biomechanics. 2016

David Feifel, et al. Treating Clinical Depression with Repetitive Deep Transcranial MagneticStimulation Using the Brainsway H1-coil. 2016

Marco Curado, et al. Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function. 2016

Woo-Jin Kim, et al. Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia. 2016

Benedikt Lauber, et al. Force and Position Control in Humans – The Role of Augmented Feedback. 2016

William J. Talkington, et al. Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality. 2015

Vianney Rozand, et al. Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation. 2015

Katharine Dunlop, et al. MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder. 2015

Paul A. Pope. Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum. 2015

Sara Tremblay, et al. The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism. 2014

Theresa Sukal-Moulton, et al. Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks. 2014

Tracy Warbrick, et al. Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies. 2014

Magdalena W. Sliwinska, et al. Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course. 2014

Riikka Möttönen, et al. Stimulating the Lip Motor Cortex with Transcranial Magnetic Stimulation. 2014

Raphael Bernier, et al. EEG Mu Rhythm in Typical and Atypical Development. 2014

Boaz Sadeh, Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation. 2014

Animal:

Vinita Batra, et al. A General Method for Evaluating Deep Brain Stimulation Effects onIntravenous Methamphetamine Self-Administration. 2016

Jaewon Beom, et al. Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain. 2016

Chia-Chien Chen, et al. Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice. 2014

Ultrasonic Stimulation

Human:

Jerome J. Lacroix, et al. Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy. 2019

Nayeli Rodríguez-Fuentes, et al. Isolation of Human Mesenchymal Stem Cells and their Cultivation on thePorous Bone Matrix. 2015

Optogenetic Stimulation

Mengye Zhu, et al. Preparation of Acute Spinal Cord Slices for Whole-cell Patch-clamp Recording in Substantia Gelatinosa Neurons. 2019

Michael Chang, et al. Generation and On-Demand Initiation of Acute Ictal Activity in Rodent andHuman Tissue. 2019

Christopher O’Shea, et al. High-Throughput Analysis of Optical Mapping Data Using Electro Map. 2019

Julia K. Sunstrum, et al. Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology. 2019

Matthew C. Arvin, et al. Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine. 2019

Erik Martinez, et al. Intracranial Pharmacotherapy and Pain Assays in Rodents. 2019

Skyler L. Jackman, et al. InVivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films. 2019

Shota Kodani, et al. Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice. 2019

Agnes Thalhammer, et al. Combining Optogenetics with Artificial microRNAs to Characterize the Effectsof Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits. 2018

Franziska Bender, et al. Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice. 2018

Bhavya Ravi, et al. Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans. 2018

Lara Eid, et al. Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons. 2018

Keith A. Lee, et al. Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats. 2018

Jonathan T. Ting, et al. Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method. 2018

Gabriella Panuccio, et al. Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays. 2018.

Xiaofan Jin, et al. High-resolution Patterned Biofilm Deposition Using pDawn-Ag43. 2018

Kaoru Yamada. InVivo Microdialysis Method to Collect Large Extracellular Proteins fromBrain Interstitial Fluid with High-molecular Weight Cut-off Probes. 2018

Caryn Porter, et al. InVivo Photolabeling of Cells in the Colon to Assess Migratory Potential of Hematopoietic Cells in Neonatal Mice. 2018

Danielle L. Kopke, et al. FM Dye Cycling at the Synapse: Comparing High Potassium Depolarization, Electrical and Channelrhodopsin Stimulation. 2018

Munenori Ono, et al. Optogenetics Identification of a Neuronal Type with a Glass Optrode in Awake Mice. 2018

David A. Clark, et al. Tracking Drosophila Larval Behavior in Response to Optogenetic Stimulation of Olfactory Neurons. 2018

Shih-Yun Chen, et al. Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains. 2018

Xiaonan Zhang, et al. Examining Monosynaptic Connections in Drosophila Using Tetrodotoxin Resistant Sodium Channels. 2018

Lifen Jiang, Yinpeng Zhan, et al. Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila. 2018

Vishnu V. Krishnamurthy, Aurora J. Turgeon, et al. Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development. 2017

Christiane Grimm, Johannes Vierock, et al. Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins. 2017

Shani Stern, Assaf Rotem, et al. External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures. 2017

Shuo Li, Sumana Raychaudhuri, et al. Flash-and-Freeze: A Novel Technique to Capture Membrane Dynamics with Electron Microscopy. 2017

Douglas K. Reilly, et al. Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons. 2017

Ilse Eidhof, Michaela Fenckova, Anna Castells Nobau, Annette Schenck, et al. High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay. 2017

Frédéric Manseau, et al. Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit. 2017

Cameron J. Stewart, et al. Design and Implementation of an Automated Illuminating, Culturing, and Sampling System for Microbial Optogenetic Applications. 2017

Daniel Haufe, et al. Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping. 2017

Michael Kyweriga, Jianjun Sun, et al. A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity. 2017

Mychal S. Grames, et al. Methods and Tips for Intravenous Administration of Adeno-associated Virus to Rats and Evaluation of Central Nervous System Transduction. 2017

Peter Lin, et al. Optogenetic Functional MRI. 2016

Sabine Schönherr, et al. Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala. 2016

Ji-Yong Kang, et al. Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons. 2016

Noriyasu Ando, et al. Insect-controlled Robot: A Mobile Robot Platform to Evaluate the Odor-tracking Capability of an Insect. 2016

Kathrin Brenker, et al. LED Thermo Flow — Combining Optogenetics with Flow Cytometry. 2016

Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer. 2016

Bin Gou, Edward Zhu, et al. High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster. 2016

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices. 2016

Michelle M. Sidor, et al. In vivo Optogenetic Stimulation of the Rodent Central Nervous System. 2015

Siobhan Robinson, et al. A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning. 2015

Colin T. E. Su, Su-In Yoon, Guillaume Marcy, et al. An Optogenetic Approach for Assessing Formation of Neuronal Connectionsin a Co-culture System. 2015

Max F.K. Happel, et al. Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning. 2015

Daniele Linaro, et al. Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond. 2015

Elliott D. Kozin, Keith N. Darrow, Ariel E. Hight, et al. Direct Visualization of the Murine Dorsal Cochlear Nucleus for Optogenetic Stimulation of the Auditory Pathway. 2015

Víctor A. Lórenz-Fonfría, Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy. 2014

Wayne I. Doyle, et al. Ex Vivo Preparations of the Intact Vomeronasal Organ and Accessory Olfactory Bulb. 2014

Victor H. Hernandez, et al. Optogenetic Stimulation of the Auditory Nerve. 2014

Alexandra K. Moore, et al. A Guide to In vivo Single-unit Recording from Optogenetically Identified Cortical Inhibitory Interneurons. 2014

Philip M. Brunetti, Ralf D. Wimmer, et al. Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probesfor Electrophysiological Recordings in Mice. 2014

James J. Jun, et al. Long-term Behavioral Tracking of Freely Swimming Weakly Electric Fish. 2014

Animal-primate:

Karam Khateeb, et al. Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images. 2019

Leah C Acker, et al. Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates. 2017

Vera K. Veith, et al. A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex. 2016